Salisbury Foundation Trust

FOI_5405

Internal Reference Number: FOI_5405

Date Request Received: 21/11/2019 08:44:25

Date Request Replied To: 19/12/2019 14:47:40

This response was sent via: By Email

Request Summary: normal ranges of liver function tests

Request Category: Researcher

 
Question Number 1:
I am undertaking a clinical audit of the normal ranges of liver function tests, and how these normal ranges were developed or established across the UK. Once we have completed the AUDIT we will share the results with you to pass on to the Head of Clinical Biochemistry or chemical pathology.
If any question is too difficult or impossible to answer, please simply return the data you have available.
I would be grateful therefore if you could provide me with the following:
1. The normal range for ALT, AST, and Alkaline phosphatase that your hospital uses for your adult patients (male and female).
 
Answer To Question 1:
I am undertaking a clinical audit of the normal ranges of liver function tests, and how these normal ranges were developed or established across the UK. Once we have completed the AUDIT we will share the results with you to pass on to the Head of Clinical Biochemistry or chemical pathology.
If any question is too difficult or impossible to answer, please simply return the data you have available.
I would be grateful therefore if you could provide me with the following:
1. The normal range for ALT, AST, and Alkaline phosphatase that your hospital uses for your adult patients (male and female).
ALT 7-35 U/L female, 10-40 U/L male
AST 15-41 U/L
ALP 30-130 U/L
 
Question Number 2:
The method used - reference and temperature, or some means for us to identify the methods used (e.g. machine name and reference to the kit used).
 
Answer To Question 2:
Beckman Coulter AU method for all.
 
Question Number 3:
How was your local normal range for each liver function test determined? And do you know the date (year) when these were last revised?
 
Answer To Question 3:
Via manufacturer.
 
Question Number 4:
How many measurements of for each of ALT, AST, and alkaline phosphatase does your laboratory undertake each year?
 
Answer To Question 4:
ALT and ALP 175133
AST 866
 
Question Number 5:
How many patients does this represent?
 
Answer To Question 5:
ALT and ALP 99174
AST 581
 
Question Number 6:
How many or what % of ALT measurements exceed your upper limit of normal. How many or what % of ALT measurements are  20U/L for women, and 31 U/L for men.
 
Answer To Question 6:
Female ALT results >ULN = 11673
Male ALT results >ULN =13391
 
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